Ligand responses of Vfr , the virulence factor regulator from Pseudomonas 1 aeruginosa 2 3
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چکیده
Jose Serate 1 , Gary P. Roberts 1 , Otto Berg 2 and Hwan Youn 3,* 4 5 Departments of Bacteriology, University of Wisconsin-Madison, Madison, Wisconsin 53706 6 Department of Chemistry, California State University at Fresno, Fresno, California 93740 7 Department of Biology, California State University at Fresno, Fresno, California 93740 8 9 10 Running title: ligand response of Vfr 11 12 13 14 15 * Corresponding author. Mailing address: 2555 East San Ramon Ave., M/S SB73, Fresno, 16 California 93740. Tel: 559-278-8305. Fax: 608-262-3963. E-mail: [email protected] 17 18 Copyright © 2011, American Society for Microbiology and/or the Listed Authors/Institutions. All Rights Reserved. J. Bacteriol. doi:10.1128/JB.00352-11 JB Accepts, published online ahead of print on 15 July 2011
منابع مشابه
Ligand responses of Vfr, the virulence factor regulator from Pseudomonas aeruginosa.
Vfr, a transcription factor homologous to the Escherichia coli cyclic AMP (cAMP) receptor protein (CRP), regulates many aspects of virulence in Pseudomonas aeruginosa. Vfr, like CRP, binds to cAMP and then recognizes its target DNA and activates transcription. Here we report that Vfr has important functional differences from CRP in terms of ligand sensing and response. First, Vfr has a signific...
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تاریخ انتشار 2011